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New Sigma Life Science and SwitchGear Genomics Project to Enable Investigation into Gene Regulation in a Variety of Biological Pathways
 10 Aug 2010: Sigma Life Science and SwitchGear Genomics announce a joint project to develop and distribute a novel microRNA (miRNA) target reporter system. Combining SwitchGear Genomics’ expertise with Sigma’s versatile lentiviral technology, these ready-to-use reporter vectors are expected to simplify miRNA target validation, enabling researchers to investigate gene regulation in a variety of biological pathways.
Sigma-Aldrich Corporation
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Sigma® Life Science Introduces World's First P53 Knockout Rat
20 Apr 2010: Sigma® Life Science introduces the world’s first p53 ‘knockout’ rat model, an important development that is expected to, due to the rat’s closer physiological and metabolic similarity to humans, significantly improve timelines for carcinogenicity screening and reduce time to market for therapeutics.
Sigma-Aldrich Corporation
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SIGMA Introduces World's First Suite of Knockout Rats for ADME/Tox Applications
09 Mar 2010: Sigma® Life Science today extended its portfolio of knockout rat models with the announcement of a new suite of models designed to facilitate more predictive absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) studies.
Sigma-Aldrich Corporation
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Screening and Profiling Protein Expression in Human Cancer Serum Using Antibody Array Technology
26 Oct 2009: In this application study by Sigma-Aldrich, antibody arrays are shown to be a powerful tool for rapid expression profiling of proteins and may potentially be applied to biomarker discovery and validation in diseased serum samples.
Sigma-Aldrich Corporation
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Sigma-Aldrich Announces SAGE™ Priority Partners
20 Oct 2009: Sigma-Aldrich® has announced the launch of the SAGE™ Priority Partners Program, through which the Company plans to build a network of researchers to evaluate the ‘knockout’ rat models it is developing to support pre-clinical research work across a number of medical fields, including Neurobiology, Toxicology, Cardiology, Immunology and others.
Sigma-Aldrich Corporation
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Sigma-Aldrich Announces SAGEspeed™ Custom Model Program for Creation of Genetically-Engineered Rodent Research Models
19 Oct 2009: Sigma-Aldrich® has announced the launch of SAGEspeed™, a program to develop human disease models in rodents using its proprietary novel CompoZr™ Zinc Finger Nuclease (ZFN) gene editing technology.
Sigma-Aldrich Corporation
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Sigma Life Science to Showcase Sigma Advanced Genetic Engineering (SAGE) Labs at Neuroscience 2009
 13 Oct 2009: Sigma Life Science launches its newest initiative, Sigma Advanced Genetic Engineering (SAGE) Labs, offering the first commercially available targeted knockout rats for disease research, using zinc finger nuclease technology. Neuroscience attendees are invited to register for an exclusive symposium on Knockout Rats in Neuroscience Research featuring experts in the field. Visit booth 653 to find out more.
Sigma-Aldrich Corporation
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Sigma-Aldrich® Receives Award from Michael J. Fox Foundation to Develop Parkinson's Disease Research Models
01 Oct 2009: Sigma-Aldrich and The Michael J. Fox Foundation have announced a collaboration that is expected to develop more accurate preclinical research models of Parkinson’s disease, a neurodegenerative disorder of unknown cause that affects nearly five million individuals worldwide.
Sigma-Aldrich Corporation
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Extraction of Nitroimidazoles from Milk and Eggs using Molecularly Imprinted Polymers
19 Aug 2009: This application note demonstrates the extraction of nitroimidazoles and metabolites from milk and egg using SupelMIP SPE. Using molecularly imprinted polymer technology, high and reproducible recoveries were observed. Extraction was conducted with a high degree of selectivity minimizing ion-suppression, allowing researchers to achieve LODs at the ppt to low ppb levels.
Sigma-Aldrich Corporation
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clinical diagnostics
